About us

We are interested in systems biology of Alzheimer’s disease. Our recent publications in this area are listed below.

10. G.-C. Han, J.-Y.Sun, J.-J.Wang, Z.-X.Bai, F.-H.Songand H.-X.Lei*.(2014) Genomics in neurological disorders.Genomics Proteomics & Bioinformatics12: 156-163.

9.  J.-Y. Sun, F.-H.Song, J.-J.Wang, G.-C.Han, Z.-X.Bai, B. Xie, X.-M.Feng,J.-P.Jia, Y. Duan and H.-X.Lei*.(2014) Hidden risk genes with high order intragenic epistasis in Alzheimer’s disease.J Alzheimers Dis,41:1039-1056.

8.  X.-M. Feng, Z.-X.Bai, J.-J.Wang, B. Xie, J.-Y.Sun, G.-C.Han, F.-H.Song, P.J. Crack, Y. Duan and H.-X.Lei*.(2014) Robust gene dys-regulation in Alzheimer’s brains. J Alzheimers Dis,41:587-597.

7.  Z.-X. Bai, B.Stamova, H. Xu, B. P. Ander,J.-J. Wang, G. C.Jickling, X. Zhan, G.-C.Han, L.-W.Jin, C.DeCarli, H.-X.Leiand F. R. Sharp.(2014) Distinctive RNA expression profiles in blood associated with Alzheimer's disease after accounting for white matter hyperintensities. Alzheimer Dis AssocDisord,online.

6.  J.-J. Wang, X.-M.Feng, Z.-X.Bai, L.-W.Jin, Y. Duan and H.-X.Lei*.(2014) Chromosome 19p in Alzheimer’s disease: when genome meets transcriptome. J Alzheimers Dis,38: 245-250.

5.  G.-C. Han, J.-J.Wang, F. Zeng, X.-M.Feng, J.Yu, H.-Y.Cao, X. Yi, H.-D.Zhou, L.-W.Jin, Y. Duan, Y.-J.Wang and H.-X.Lei*.(2013) Characteristic transformation of blood transcriptome in Alzheimer’s disease.J Alzheimers Dis,35: 373-386.

4.  J.-Y. Sun, Y.-Y.Pan, X.-M.Feng, H.-J.Zhang, Y. Duan and H.-X.Lei*.(2013) iBIG: an integrative network tool for supporting human disease mechanism studies. Genomics Proteomics & Bioinformatics11: 166-171.

3.  D.-P. Liang, G.-C.Han, X.-M.Feng, J.-Y.Sun, Y. Duan andH.-X.Lei*. (2012) Concerted perturbation observed in a hub network in Alzheimer’s disease. PLoS One,7(7): e40498

2.  J.-Y. Sun, X.-M.Feng, D.-P.Liang, Y. Duan andH.-X.Lei*. (2012) Down-regulation of energy metabolism in Alzheimer’s disease is a protective response of neurons to the microenvironment. J Alzheimers Dis,28, 389-402

1.  H.-X.Lei*.(2010) Amyloid and Alzheimer’s disease.Protein & Cell,1(4), 312-314

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  Beijing Institute of Genomics, CAS
  Lei Hongxing Group, Beijing Institute of Genomics, CAS